Herbalist throughout Southeast Asia have used the neem tree successfully for centuries to reduce tumors. Researches in India, Europe and Japan have now found that poly- saccharides and limonoids found in neem bark, leaves and seed oil reduced tumors and cancers, and showed effectiveness against lymphocytic leukemia. In several patents issued in Japan hot water neem bark extracts showed remarkable effectiveness against several types of tumors. Several types of extract were tested at different doses and compared to the effectiveness of a standard anti-cancer agent. Several of the extracts were equal to or better than the standard anti-cancer agent against solid tumors. When the tests were done using a more purified extract of neem bark, the results were even more impressive against solid tumors. But the extracts tested were still very crude when compared to the extremely purified active compounds typically used in treating tumors. Further studies using truly pure active compounds are expected to produce results at least equal to the control. Another researcher used an extract of neem leaves to prevent the adhesion of cancer cells to other cells in the body. Without the ability to stick to other cells, cancers cannot spread through the body and are more easily destroyed by the body's own immune system or by other treatments. In general, neem is known for ability to effect cancers. Injections of neem extract around tumors showed remarkable reduction in size in just a few week. Skin cancers may be particularly responsive to neem. A number of reports have been made by patients that skin cancers have disappeared after several months of daily application of a neem-based cream