Arthritis is broad term covering many types of joint ailments. The ailments can be autoimmune disorders, infections, and the results of wear on the joints or simply inflammation. Generally thought it is the inflammation or the pain associated whit it that is treated regardless of the origin. Neem can aid in treating arthritis in many ways. Neem's antibacterial properties can help kills infectious causes while its inflammation reducing properties can alleviate the symptoms. Neem can also help create a balance in the immune systems, which directly affects progression of the disease.
A number of studies indicate the usefulness of neem in treating arthritis. There have been numerous studies on the ability of extracts of neem leaf to reduce the inflammation caused by arthritis. One study suggested that the phenolic compounds containing catechin (known to posses anti-inflammatory properties) may produce the anti-inflammatory effects witnessed. Another study discovered quercetin, a known antibacterial compound, in neem leaves. Others conclude that the polysaccharides in neem reduces the inflammation and swelling associated with arthritis.
Different parts of the tree and many extracts of each were tested. Compounds, like nimbidin, extracted from the seed with alcohol, showed significant effects against arthritis, as have methanol extracts of the leaf and bark. The reason these compounds work is believed to be due to several factors. Several leaf compounds have been shown to be more potent inhibitors or prostaglandin than aspirin. Limonoids and catechin in the leaf and seed, may provide additional beneficial effects. Others possible explanations point to an inhibition of the release of mediators of acute inflammation. An antihistaminic effect of nimbidin (underlying its anti-gastric ulcer activity) has been reported. Also, a modification of immune response appears to reduce the generation of inflammation-producing chemicals.
In any case, the long history of using neem leaf, bark and seed extracts to relieve inflamed joints is borne out by the recent scientific investigation. Treatment for arthritis is traditionally a mild neem leaf tea coupled with rubbing a warmed neem-based cream on the stiff or painful areas as needed.